To what extent can knowledge of tumour associated antigens be useful Essay

To what extent can knowledge of tumour associated antigens be useful in the management of cancer patients Illustrate your answe - Essay Example This research paper is focused on basic attempts of TAAs identification and the role they play for different types of tumors. TAAS vs Cancer The important role of tumor associated antigens (TAAs) can be explained in the following way: they are present in cancer cells and can cause a powerful antitumor immune response among patients with lung carcinoma or any other type of cancer. There are the following types of identified TAAs: MAGE and BAGE families, gp 100, SART-1, tyrosinase, MUC-1 and others (Akimov, 2004). They are used by immunotherapy for treating cancer. Nevertheless, there is no satisfactorily level of this kind of treatment (Danussi, Coslovi, Campa, Mucignat, Spessotto, Uggeri, Paoletti, Colombatti, 2009). Therefore, there is a need to focus more on identification of TAAs and available TAAs to target. There is an option to identify TAAS with the help of â€Å"serological analysis of recombinant c DNA expression libraries (SEREX), using tumor mRNA and autologous serum from a patients with NSCLC. SEREX analysis of a range of different human tumor types has identified a number of tumor antigens with diagnostic and therapeutic potential† (Akimov, 2004). Different approaches are being currently developed and it is of high importance for the modern researchers and scientists to identify relevance of TAAs in dealing with different types of cancer. ... MAGE-3 is the most broadly known CT antigen, which is the first and foremost target for cancer vaccines (Slovin, Ragupathi, Fernandez, Diani, Jefferson, Wilton, Kelly, Morris, Solit, Clausen, Livingston, Scher, 2007). On the basis of different researchers and laboratory experiments, the scientists are looking for a correlation between TAAs identification and assessment of patient’s cell’s response to TAA’s. Strategies for vaccine development have been correlated with identification and management of TAAs. Highly attractive targets for cancer vaccines are cancer testis (CT) antigens. These antigens are applicable for different forms of various human cancers. In accordance with current data, â€Å"MAGE antigens are expressed in about 40% of non-small-cell lung cancer (NSCLC) cases [8]. In summary, this analysis provided further insights in the immunogenicity of lung cancer with respect to antigen specific humoral and cellular immune responses† (Vonderheide, 2002). There is a clear tendency to find out universal antigens. The most serious preventive factor for a proper searching for TAAs is that different patients with different forms of cancer have not been treated by a so-called â€Å"universal† TAAs. Therefore, there is a need for universal tumor-associated antigens. Consequently, the modern scientists and researchers are focused on searching for a new type of TAAs dealing with different types of tumor. One of the most optimal methods is â€Å"epitope deduction†, which begins with a number of database analyses focused on appropriate gene products’ selection and further scanning of the deduced protein sequence for peptides, known as MHC binding motifs (Vonderheide, 2002). This method is independent from the existence of an innate anti-tumor T-cell

Arts Administration Essay Example | Topics and Well Written Essays - 2000 words

Arts Administration - Essay Example Organizations are feeling the need to address the problem of the deficit brought about by the problems in the economy (Bonser, 2005). Arts administrators have been very much needed the past few years in various profit and non-profit organizations dedicated to the culture and the arts. This only proves that the society and the economy that caters to arts are already embracing the business component of their endeavors (Bonser, 2005). Choosing arts administration as a field of study can open up to various possibilities in the arts industry. It also promises a big contribution to the society. Arts administrators, dedicated and well-trained, are expected to help the arts institutions to confront the financial situation and organizational limits and to cater to the interests and needs of the clients and enthusiasts. At the same time, the arts administrators are also expected to have the understanding of what counts in the artistic community (Bonser, 2005). In the United States alone, there are various schools that offer Arts Administration program. These schools and universities offer considerable courses for their students and they have very comprehensive curriculum. These institutions are known for their strong commitment in developing the capabilities and skills of the students, thereby providing a strong support to the current state and the future of the arts community (Bonser, 2005). Fashion Institute of Technology The Fashion Institute of Technology or FIT is located in New York. The school is based in the middle of the city, just perfect for the institute which provides a link between creativity and commerce. It provides academic programs for students who want a career in the arts industry with at least 30 fields to choose from. The courses vary from the Master's to Bachelor's and Associate's Degree. The programs vary. There is the credit certificate program, online course and international programs (FIT, 2006). FIT recognizes the need to go beyond instilling among the students a good background in history of the arts. This is why a number of the programs FIT offers today also teach skills in technology and business. The Fashion Institute of Technology has Associate Degree and Bachelor of Science Degree Programs that have a comprehensive curriculum, covering a specific arts field and the other disciplines required in management for that specific field. Some of these programs are the Fashion Merchandising Management, Production Management and Visual Management. They incorporate the significant resources of the school in the field of Arts and Design, Liberal Arts, and Business and Technology. Through this, school aims to be able to develop the communication and business skills among the students (FIT, 2006). FIT also offers Arts Administration in its Graduate Program in Art Market: Principles and Practice. This was formerly known as the Gallery and Retail Art Administration. It prepares its students for careers in art galleries, auction houses, art market services or public art administration. There are classes in art history and history of collecting. There are also courses tackling practical disciplines like art law, professional ethics, design and management of galleries, business and marketing. Applicants for the graduate program must